• 1x 5 μm FFPE tissue section -> 50-600 mm²

  • 1x 10 μm FFPE tissue section -> 25-300 mm²

  • Neoplastic cells ≥20% - if less, macrodissection is required

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Description

The fully automated IdyllaTM MSI Test performs the detection of microsatellite instability directly from formalin-fixed paraffin embedded (FFPE) human cancer tissue sections utilizing a PCR reaction followed by high-resolution melting curve analysis. The fully automated samples-to-result process with integrated automated software interpretation and reporting makes this MSI analysis fast and easy-to-use in virtually any laboratory setting.

The fully automated IdyllaTM MSI Test performs detection of mutations in 7 novel MSI loci (ACVR2A, BTBD7, DIDO1, MRE11, RYR3, SEC31A, and SULF2). These biomarkers are tumor-specific, show a high frequency in colorectal cancer and are stable across different ethnicities ensuring excellent specificity of the test. In addition, these tumor-specific biomarkers do not require the analysis of paired normal tissue samples associated with traditional MSI/dMMR testing.

With its high concordance (> 97%) and low failure rates compared to standard methods, the IdyllaTM MSI Test provides a fast, convenient and reliable alternative for any lab.

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